Oxaliplatin [oxaliplatin]
- Terms
-
Eloxatin
oxaliplatina
-
1,2-Diaminocyclohexane Platinum Oxalate
1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II)
ACT 078
ACT-078
Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II)
Eloxatin
Eloxatine
L-OHP Cpd
Oxalato-(1,2-cyclohexanediamine)platinum II
Oxaliplatin, (SP-4-2-(1R-trans))-isomer
Oxaliplatin, (SP-4-2-(1S-trans))-isomer
Oxaliplatin, (SP-4-3-(cis))-isomer
Oxaliplatine
Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
Platinum(II)-1,2-cyclohexanediamine Oxalate
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
- DUI
- D000077150 MeSH Browser
- CUI
- M0095550
- History note
- 2019 (1981)
- Public note
- 2019; OXALIPLATIN was indexed under ORGANOPLATINUM COMPOUNDS 1981-2018
Allowable subheadings
- AD
- administration & dosage 4
- AE
- adverse effects 7
- AG
- agonists
- AA
- analogs & derivatives
- AN
- analysis 1
- AI
- antagonists & inhibitors
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 2
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification 1
- ME
- metabolism
- PK
- pharmacokinetics 1
- PD
- pharmacology 10
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 17
- TO
- toxicity 1
- UR
- urine