Leflunomide [leflunomid]
topical
36
- Terms
-
Arava
-
Arava
HWA 486
HWA-486
N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
SU101
Persistent link
https://www.medvik.cz/link/D000077339
Definition
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
- DUI
- D000077339 MeSH Browser
- CUI
- M0132172
- CAS
- 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-
- History note
- 2019 (1985)
- Public note
- 2019; LEFLUNOMIDE was indexed under ISOXAZOLES 1991-2018; and under OXAZOLES 1985-1990
Allowable subheadings
- AD
- administration & dosage 5
- AE
- adverse effects 6
- AG
- agonists
- AA
- analogs & derivatives 8
- AN
- analysis
- AI
- antagonists & inhibitors
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics 1
- PD
- pharmacology 7
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 11
- TO
- toxicity
- UR
- urine
...
Occurrences in Medvik records
D
Chemicals and Drugs