Anaplastic Lymphoma Kinase [anaplastická lymfomová kináza]
- Terms
-
ALK
ALK receptorová tyrosinkináza
antigen CD246
kináza anaplastického lymfomu
-
ALK Kinase
ALK Tyrosine Kinase Receptor
Anaplastic Lymphoma Receptor Tyrosine Kinase
CD246 Antigen
NPM-ALK
Nucleophosmin-Anaplastic Lymphoma Kinase
A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.
- DUI
- D000077548 MeSH Browser
- CUI
- M0228330
- History note
- 2019 (1994)
- Public note
- 2019; ANAPLASTIC LYMPHOMA KINASE was indexed under RECEPTOR PROTEIN-TYROSINE KINASES 2012-2018; and under PROTEIN-TYROSINE KINASES 1994-2011
Allowable subheadings
- AD
- administration & dosage 1
- AG
- agonists
- AN
- analysis 3
- AI
- antagonists & inhibitors 38
- BI
- biosynthesis
- BL
- blood
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects 7
- GE
- genetics 34
- HI
- history
- IM
- immunology 1
- IP
- isolation & purification
- ME
- metabolism 8
- PH
- physiology 2
- RE
- radiation effects
- TU
- therapeutic use 4
- UL
- ultrastructure
ALK protein, human Chemical MeSH Browser
Alk protein, mouse Chemical MeSH Browser
Alk protein, rat Chemical MeSH Browser