T-Cell Exhaustion [vyčerpání T-buněk]

topical
Terms

T-Lymphocyte Exhaustion

Persistent link   https://www.medvik.cz/link/D000094383
Definition

Progressive deterioration of T-cell function due to chronic antigen stimulation and inflammatory signals, e.g., CHRONIC INFECTION and CANCER. T-cell exhaustion is characterized by weakened immune system, e.g., dysfunctional MEMORY T CELLS differentiation and EPIGENETIC REPRESSION of IMMUNOLOGIC MEMORY effector functions.

DUI
D000094383 MeSH Browser
CUI
M000755906
History note
2023
Public note
2023

Allowable subheadings

DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects

G Phenomena and Processes
G01 Physical Phenomena 79
G02 Chemical Phenomena 308
G03 Metabolism 1 199
G03 Metabolic Phenomena obsolete
G04 Cell Physiological Phenomena 515
G05 Genetic Phenomena 135
G06 Microbiological Phenomena 96
G07 Physiological Phenomena 176
G08 Reproductive and Urinary Physiological Phenomena 18
G09 Circulatory and Respiratory Physiological Phenomena 94
G10 Digestive System and Oral Physiological Phenomena 4
G11 Musculoskeletal and Neural Physiological Phenomena 17
G12 Immune System Phenomena 249
G12.590 Immune System Exhaustion
G12.590.500 T-Cell Exhaustion
G13 Integumentary System Physiological Phenomena 14
G14 Ocular Physiological Phenomena 148
G15 Plant Physiological Phenomena 158
G16 Biological Phenomena 130
G17 Mathematical Concepts 66

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