The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a killer cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

DUI

D000920 MeSH Browser

CUI

M0001370

Previous indexing

Cytotoxicity Tests, Immunologic (1971-1977); Immunity, Cellular (1970-1977); Lymphocytes (1966-1977)

History note

78

Public note

78