Botulinum Toxins [botulotoxiny]
- Terms
-
botulin
jed klobásový
klobásový jed
-
Botulin
Botulinum Neurotoxin
Botulinum Neurotoxins
Botulinum Toxin
Clostridium botulinum Toxins
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
- Annotation
- /antag permitted but consider also BOTULINUM ANTITOXIN
- podheslo /antagonisté a inhibitory je povolené, ale zvaž také deskriptor BOTULINOVÝ ANTITOXIN
- DUI
- D001905 MeSH Browser
- CUI
- M0002844
- Previous indexing
- Clostridium Botulinum (1966-1968); Toxins (1966-1968)
- History note
- 78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71)
- Online note
- use BOTULINUM TOXINS to search BOTULINUM TOXIN 1969-77 (as Prov 1969-71)
- Public note
- 78; was BOTULINUM TOXIN 1972-77
Allowable subheadings
- AD
- administration & dosage 62
- AE
- adverse effects 30
- AG
- agonists
- AN
- analysis 7
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis
- BL
- blood 3
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 5
- CL
- classification 7
- DE
- drug effects
- EC
- economics 1
- GE
- genetics 1
- HI
- history 3
- IM
- immunology 1
- IP
- isolation & purification 6
- ME
- metabolism 2
- PK
- pharmacokinetics 2
- PD
- pharmacology 34
- PH
- physiology 3
- PO
- poisoning 8
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 178
- TO
- toxicity 12
- UL
- ultrastructure
- UR
- urine
CNBTX-A Chemical MeSH Browser
Clostridium botulinum L toxin Chemical MeSH Browser
Clostridium botulinum LL toxin Chemical MeSH Browser
Clostridium botulinum M toxin Chemical MeSH Browser
NTNH protein, Clostridium botulinum Chemical MeSH Browser
SXN101959 Chemical MeSH Browser
botulinum toxin type C Chemical MeSH Browser
botulinum toxin type D Chemical MeSH Browser
botulinum toxin type E Chemical MeSH Browser
botulinum toxin type F Chemical MeSH Browser
botulinum toxin type G Chemical MeSH Browser
exoenzyme C3, Clostridium botulinum Chemical MeSH Browser
hemagglutinin 33 protein, Clostridium botulinum Chemical MeSH Browser