Tetanus Toxin [tetanový toxin]
- Terms
-
klostridiální neurotoxin
-
Clostridial Neurotoxin
Clostridium tetani Toxin
Tetanus Toxins
Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
- Annotation
- /antag permitted but consider also TETANUS ANTITOXIN
- DUI
- D013744 MeSH Browser
- CUI
- M0021202
- History note
- 65
- Public note
- 65
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects 2
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 2
- CL
- classification
- EC
- economics
- GE
- genetics 3
- HI
- history
- IM
- immunology
- IP
- isolation & purification 3
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology 2
- PH
- physiology
- PO
- poisoning 1
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity 9
- UR
- urine
P30 tetanus toxin peptide Chemical MeSH Browser
azo-GnRH tetanus toxoid conjugate Chemical MeSH Browser
tetanolysin Chemical MeSH Browser
tetanospasmin Chemical MeSH Browser
tetanus toxin (947-966) Chemical MeSH Browser
tetanus toxin fragment BIIb Chemical MeSH Browser
tetanus toxin fragment C Chemical MeSH Browser
zinc-endopeptidase, tetanus neurotoxin Chemical MeSH Browser