A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.

Annotation

for buprenorphine maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT

DUI

D002047 MeSH Browser

CUI

M0003054

CAS

6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-

Previous indexing

Dihydromorphinone (1966-1968); Morphine (1966-1968); Morphinans (1969-1978)

History note

87(79); was see under MORPHINANS 1979-86

Public note

87; was see under MORPHINANS 1979-86