Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.

Annotation

/biosyn permitted if by living matter

DUI

D002969 MeSH Browser

CUI

M0004546

Previous indexing

Amidohydrolases (1966-1978); Penicillinase (1966-1978); Amides (1966-1973); Lactams (1974-1982); beta-Lactamases (1979-1982)

History note

83

Public note

83