Clavulanic Acids [kyseliny klavulanové]
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
- Annotation
- /biosyn permitted if by living matter
- DUI
- D002969 MeSH Browser
- CUI
- M0004546
- Previous indexing
- Amidohydrolases (1966-1978); Penicillinase (1966-1978); Amides (1966-1973); Lactams (1974-1982); beta-Lactamases (1979-1982)
- History note
- 83
- Public note
- 83
Allowable subheadings
- AD
- administration & dosage 2
- AE
- adverse effects 2
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology 4
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 5
- TO
- toxicity
- UR
- urine
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9-O-methylclavulanate Chemical MeSH Browser
9-deoxyclavulanic acid Chemical MeSH Browser
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