Complement C1s [komplement C1s]
topical
4
- Terms
-
C1-esterasa
C1-esteráza
C1s komplement
komplement 1 esterasa
komplement 1s
-
C 1 Esterase
C1 Esterase
C1s Complement
Complement 1 Esterase
Complement 1s
Complement Component 1s
Persistent link
https://www.medvik.cz/link/D003173
Definition
A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
- DUI
- D003173 MeSH Browser
- CUI
- M0004925
- Previous indexing
- Esterases (1966-1977); Complement 1 (1975-1977)
- History note
- 2006 (1978)
- Public note
- 2006; see COMPLEMENT 1S 1990-2005; for COMPLEMENT 1 ESTERASE see COMPLEMENT ACTIVATING ENZYMES 1978-1989
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency 1
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
...
Occurrences in Medvik records