Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia.

DUI

D003444 MeSH Browser

CUI

M0005369

History note

91(75); was see under SHOCK, TRAUMATIC 1979-90; was see under KIDNEY FAILURE, ACUTE 1967-78; was see under ACUTE RENAL FAILURE 1963-66

Online note

use KIDNEY FAILURE, ACUTE to search CRUSH SYNDROME 1966-74

Public note

91; was see under SHOCK, TRAUMATIC 1979-90; was see under KIDNEY FAILURE, ACUTE 1967-78; was see under ACUTE KIDNEY FAILURE 1963-66