Dactinomycin [daktinomycin]
- Terms
-
Actinomycin
actinomycin D
dactinomycin
-
Actinomycin
Actinomycin D
Cosmegen
Cosmegen Lyovac
Lyovac-Cosmegen
Meractinomycin
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
- DUI
- D003609 MeSH Browser
- CUI
- M0005644
- CAS
- Actinomycin D
- History note
- 66; ACTINOMYCIN was heading 1963-95
- Public note
- 66; ACTINOMYCIN was heading 1963-95
Allowable subheadings
- AD
- administration & dosage 7
- AE
- adverse effects
- AG
- agonists
- AA
- analogs & derivatives 1
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis 1
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics 1
- PD
- pharmacology 43
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 4
- TO
- toxicity
- UR
- urine
Kengshenmycin Chemical MeSH Browser
actinomycin D-dATGCAT complex Chemical MeSH Browser
actinomycin G Chemical MeSH Browser
aurantin Chemical MeSH Browser