Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.

Annotation

differentiate from DRUG RESISTANCE; not for tolerability ( = drug /adv eff): Manual 28.19

DUI

D004361 MeSH Browser

CUI

M0006854