Glutamate Decarboxylase [glutamát dekarboxyláza]

topical
70
Terms

dekarboxyláza kyseliny glutamové
GAD
glutamátdekarboxylasa
glutamátdekarboxyláza

 

Glutamate Carboxy-Lyase
Glutamic Acid Decarboxylase

Persistent link   https://www.medvik.cz/link/D005968
Definition

A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.

DUI
D005968 MeSH Browser
CUI
M0009373
CAS
L-Glutamate-1-carboxy-lyase
Previous indexing
Carboxy-Lyases (1973-1974); Glutamates (1973-1974)
History note
84(75); was see under CARBOXY-LYASES 1975-83
Public note
84; was see under CARBOXY-LYASES 1975-83

Allowable subheadings

AD
administration & dosage 1
AE
adverse effects
AN
analysis 2
AI
antagonists & inhibitors 10
BI
biosynthesis
BL
blood 5
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 2
CL
classification
DF
deficiency 1
DE
drug effects 2
EC
economics
GE
genetics 3
HI
history
IM
immunology 33
IP
isolation & purification 1
ME
metabolism 7
PK
pharmacokinetics
PD
pharmacology 1
PH
physiology 6
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 2
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D01 Inorganic Chemicals 68
D02 Organic Chemicals 391
D03 Heterocyclic Compounds 190
D04 Polycyclic Compounds 65
D05 Macromolecular Substances 103
D06 Hormones, Hormone Substitutes, and Hormone Antagonists 43
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 551
D08.811.520 Lyases 22
D08.811.520.224 Carbon-Carbon Lyases 4
D08.811.520.224.125 Carboxy-Lyases 25
D08.811.520.224.125.050 Adenosylmethionine Decarboxylase
D08.811.520.224.125.100 Aromatic-L-Amino-Acid Decarboxylases 17
D08.811.520.224.125.250 Glutamate Decarboxylase 70
D08.811.520.224.125.300 Histidine Decarboxylase 1
D08.811.520.224.125.350 Indole-3-Glycerol-Phosphate Synthase 1
D08.811.520.224.125.387 Methylmalonyl-CoA Decarboxylase
D08.811.520.224.125.425 Ornithine Decarboxylase 16
D08.811.520.224.125.450 Orotidine-5'-Phosphate Decarboxylase 1
D08.811.520.224.125.500 Phosphoenolpyruvate Carboxykinase (ATP) 4
D08.811.520.224.125.550 Phosphoenolpyruvate Carboxykinase (GTP) 1
D08.811.520.224.125.650 Phosphoenolpyruvate Carboxylase 5
D08.811.520.224.125.750 Pyruvate Decarboxylase 1
D08.811.520.224.125.800 Ribulose-Bisphosphate Carboxylase 10
D08.811.520.224.125.875 Tyrosine Decarboxylase 4
D08.811.520.224.125.900 Uroporphyrinogen Decarboxylase 5
D09 Carbohydrates 724
D10 Lipids 2 528
D12 Amino Acids, Peptides, and Proteins 16
D13 Nucleic Acids, Nucleotides, and Nucleosides 9
D20 Complex Mixtures 19
D23 Biological Factors 143
D25 Biomedical and Dental Materials 110
D26 Pharmaceutical Preparations 7 045
D27 Chemical Actions and Uses 374

ERT D1 protein, Lycopersicon esculentum Chemical MeSH Browser

GAD55, human Chemical MeSH Browser

GAD65 (217-236) Chemical MeSH Browser

GAD65 (524-543) Chemical MeSH Browser

GAD65 (96-585) Chemical MeSH Browser

GAD65(370-575), human Chemical MeSH Browser

aspartate-alpha-decarboxylase Chemical MeSH Browser

b protein, Drosophila Chemical MeSH Browser

gadA protein, E coli Chemical MeSH Browser

gadB protein, E coli Chemical MeSH Browser

glutamate decarboxylase 1 Chemical MeSH Browser

glutamate decarboxylase 2 Chemical MeSH Browser

glutamate decarboxylase 65 (202-221) Chemical MeSH Browser

glutamic acid decarboxylase 65 (524-543), mouse Chemical MeSH Browser

Add