Insulin [inzulin]
- Terms
-
insulin
inzulín
inzulinový řetězec A
inzulinový řetězec B
krystalický inzulin
regular inzulin
rozpustný inzulin
-
Iletin
Insulin A Chain
Insulin B Chain
Insulin, Regular
Novolin
Sodium Insulin
Soluble Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
- Annotation
- /blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available
- DUI
- D007328 MeSH Browser
- CUI
- M0011417
Combination
- antagonists & inhibitors
- Insulin Antagonists
Allowable subheadings
- AD
- administration & dosage 1 194
- AE
- adverse effects 231
- AG
- agonists 8
- AA
- analogs & derivatives 552
- AN
- analysis 100
- BI
- biosynthesis 34
- BL
- blood 406
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 14
- CH
- chemistry 56
- CL
- classification 40
- DF
- deficiency 43
- EC
- economics 17
- GE
- genetics 42
- HI
- history 68
- IM
- immunology 36
- IP
- isolation & purification 39
- ME
- metabolism 393
- PK
- pharmacokinetics 62
- PD
- pharmacology 357
- PH
- physiology 141
- PO
- poisoning 0
- RE
- radiation effects 5
- ST
- standards 13
- SD
- supply & distribution 7
- TU
- therapeutic use 1 284
- TO
- toxicity 4
- UR
- urine 0