Islets of Langerhans [Langerhansovy ostrůvky]

topical
231
Terms

Islands of Langerhans
Islet Cells
Nesidioblasts
Pancreas, Endocrine
Pancreatic Islets

Persistent link   https://www.medvik.cz/link/D007515
Definition

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Annotation
do not confuse with LANGERHANS CELLS (skin); neoplasms = ADENOMA, ISLET CELL or CARCINOMA, ISLET CELL or their specifics
DUI
D007515 MeSH Browser
CUI
M0011741
History note
91; was ISLANDS OF LANGERHANS 1963-90
Online note
use ISLETS OF LANGERHANS to search ISLANDS OF LANGERHANS 1966-90
Public note
91; was ISLANDS OF LANGERHANS 1963-90

A Anatomy
A03.734 Pancreas 920
A03.734.414 Islets of Langerhans 231
A03.734.414.065 Glucagon-Secreting Cells 6
A03.734.414.131 Insulin-Secreting Cells 202
A03.734.540 Pancreas, Exocrine 29
A03.734.667 Pancreatic Ducts 56
A06.300 Endocrine Glands 187
A06.300.071 Adrenal Glands 453
A06.300.312 Gonads 136
A06.300.414 Islets of Langerhans 231
A06.300.414.043 Glucagon-Secreting Cells 6
A06.300.414.087 Insulin-Secreting Cells 202
A06.300.560 Parathyroid Glands 135
A06.300.635 Pineal Gland 181
A06.300.747 Pituitary Gland 459
A06.300.900 Thyroid Gland 1 166