Isocitrate Dehydrogenase [isocitrátdehydrogenasa]

topical
55
Terms

isocitrátdehydrogenasa I
isocitrátdehydrogenáza
izocitrátdehydrogenáza
izocitrátdehydrogenáza 1

 

Isocitrate Dehydrogenase (NAD+)
Isocitrate Dehydrogenase-I
NAD Isocitrate Dehydrogenase

Persistent link   https://www.medvik.cz/link/D007521
Definition

An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.

DUI
D007521 MeSH Browser
CUI
M0011751
CAS
Isocitrate:NAD+ oxidoreductase (decarboxylating)
History note
65(63)
Public note
65

Allowable subheadings

AD
administration & dosage 1
AE
adverse effects
AN
analysis 3
AI
antagonists & inhibitors 6
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 4
CL
classification
DF
deficiency 1
DE
drug effects 2
EC
economics
GE
genetics 36
HI
history
IM
immunology
IP
isolation & purification 1
ME
metabolism 19
PK
pharmacokinetics
PD
pharmacology
PH
physiology 3
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 2
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D01 Inorganic Chemicals 68
D02 Organic Chemicals 391
D03 Heterocyclic Compounds 189
D04 Polycyclic Compounds 65
D05 Macromolecular Substances 103
D06 Hormones, Hormone Substitutes, and Hormone Antagonists 43
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.682 Oxidoreductases 446
D08.811.682.047 Alcohol Oxidoreductases 97
D08.811.682.047.820 NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
D08.811.682.047.820.100 11-beta-Hydroxysteroid Dehydrogenases 16
D08.811.682.047.820.125 20-Hydroxysteroid Dehydrogenases 7
D08.811.682.047.820.150 3-Hydroxyacyl CoA Dehydrogenases 15
D08.811.682.047.820.186 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) 2
D08.811.682.047.820.193 3-Isopropylmalate Dehydrogenase
D08.811.682.047.820.196 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase
D08.811.682.047.820.200 Acetoin Dehydrogenase
D08.811.682.047.820.250 Alcohol Dehydrogenase 55
D08.811.682.047.820.284 Aldo-Keto Reductases 3
D08.811.682.047.820.289 Carbonyl Reductase (NADPH) 2
D08.811.682.047.820.293 Glycerol-3-Phosphate Dehydrogenase (NAD+) 1
D08.811.682.047.820.300 Homoserine Dehydrogenase 1
D08.811.682.047.820.350 Hydroxybutyrate Dehydrogenase 5
D08.811.682.047.820.375 Hydroxyprostaglandin Dehydrogenases 10
D08.811.682.047.820.400 Hydroxypyruvate Reductase
D08.811.682.047.820.450 IMP Dehydrogenase 2
D08.811.682.047.820.475 Isocitrate Dehydrogenase 55
D08.811.682.047.820.487 Ketol-Acid Reductoisomerase 1
D08.811.682.047.820.493 L-Lactate Dehydrogenase 242
D08.811.682.047.820.496 Malate Dehydrogenase 88
D08.811.682.047.820.498 Malate Dehydrogenase (NADP+) 1
D08.811.682.047.820.500 Progesterone Reductase 2
D08.811.682.047.820.800 D-Xylulose Reductase
D08.811.682.047.820.900 Short Chain Dehydrogenase-Reductases 2
D09 Carbohydrates 723
D10 Lipids 2 524
D12 Amino Acids, Peptides, and Proteins 16
D13 Nucleic Acids, Nucleotides, and Nucleosides 9
D20 Complex Mixtures 19
D23 Biological Factors 143
D25 Biomedical and Dental Materials 110
D26 Pharmaceutical Preparations 7 034
D27 Chemical Actions and Uses 374

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