A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.

DUI

D007559 MeSH Browser

CUI

M0011815

CAS

Ivermectin

Previous indexing

Anthelmintics (1966-1986); Antinematodal Agents (1974-1986); Antiprotozoal Agents (1966-1986); Filaricides (1973-1986); Insecticides (1966-1986); Lactones (1966-1986)

History note

1987; for MECTIZAN use IVERMECTIN (NM) 1987-1999

Public note

1987; for MECTIZAN see IVERMECTIN 1987-1999