A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.

DUI

D008148 MeSH Browser

CUI

M0012707

CAS

Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-

Previous indexing

Anticholesteremic Agents (1966-1987); Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors (1977-1987); Naphthalenes (1966-1987)

History note

88; for MONACOLIN K use LOVASTATIN (NM) 1980-98

Public note

88; MONACOLIN K was indexed under NAPHTHALENES 1981-98 & ANTIBIOTICS 1980