A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.

DUI

D019821 MeSH Browser

CUI

M0029425

Previous indexing

Lovastatin/analogs & derivatives (1988-1997); Naphthalenes (1986-1987)

History note

98; use SIMVASTATIN (NM) 1986-97

Public note

98; SIMVASTATIN was indexed under LOVASTATIN/analogs & derivatives 1988-97 & NAPHTHALENES 1986-87