Phenytoin [fenytoin]
- Terms
-
difenylhydantoin
difenylthiohydantoin
-
5,5-Diphenylhydantoin
5,5-diphenylimidazolidine-2,4-dione
Antisacer
Difenin
Dihydan
Dilantin
Diphenylhydantoin
Epamin
Epanutin
Fenitoin
Hydantol
Phenhydan
Phenytoin Sodium
Sodium Diphenylhydantoinate
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
- DUI
- D010672 MeSH Browser
- CUI
- M0016580
- CAS
- 2,4-Imidazolidinedione, 5,5-diphenyl-
- History note
- 78; was DIPHENYLHYDANTOIN 1963-77
- Online note
- use PHENYTOIN to search DIPHENYLHYDANTOIN 1966-77
- Public note
- 78; was DIPHENYLHYDANTOIN 1963-77
Allowable subheadings
- AD
- administration & dosage 32
- AE
- adverse effects 36
- AG
- agonists
- AA
- analogs & derivatives 1
- AN
- analysis 7
- AI
- antagonists & inhibitors
- BL
- blood 13
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 3
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 6
- PK
- pharmacokinetics 10
- PD
- pharmacology 25
- PO
- poisoning 2
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution 1
- TU
- therapeutic use 44
- TO
- toxicity 8
- UR
- urine 1
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