Proinsulin [proinsulin]
- Terms
-
proinzulin
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
- DUI
- D011384 MeSH Browser
- CUI
- M0017685
- CAS
- Proinsulin
- Previous indexing
- Insulin (1966-1971)
- History note
- 72
- Public note
- 72
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood 7
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 2
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 2
- HI
- history 1
- IM
- immunology 1
- IP
- isolation & purification 1
- ME
- metabolism 3
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology 2
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
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methionyl-lysylproinsulin Chemical MeSH Browser
miniproinsulin Chemical MeSH Browser
proinsulin (46-70) Chemical MeSH Browser
proinsulin, des(31,32)- Chemical MeSH Browser
proinsulin, des(Lys(64),Arg(65)) Chemical MeSH Browser
proinsulin, des-(23-63)- Chemical MeSH Browser
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