An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

Annotation

reserpine derivatives=RESERPINE /analogs

DUI

D012110 MeSH Browser

CUI

M0018861

CAS

Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)-

History note

RESERPINE DERIVATIVES was see under RESERPINE 1975-77, was see under YOHIMBANS 1969-74; /adv eff-pois-tox was RESERPINE TOXICOLOGY 1963-65

Online note

use RESERPINE to search RESERPINE DERIVATIVES 1975-77; use YOHIMBANS 1969-74

Public note

RESERPINE DERIVATIVES was see under RESERPINE 1975-77, was see under YOHIMBANS 1969-74; /adverse effects /poisoning /toxicity were RESERPINE TOXICOLOGY 1963-65