Sphingomyelin Phosphodiesterase [sfingomyelinfosfodiesterasa]

topical
21
Terms

sfingomyelinasa
sfingomyelinasa C
sfingomyelináza
sfingomyelináza C
sfingomyelinfosfodiesteráza

 

Sphingomyelin Cholinephosphohydrolase
Sphingomyelin Cleaving Enzyme
Sphingomyelinase
Sphingomyelinase C

Persistent link   https://www.medvik.cz/link/D013108
Definition

An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.

Annotation
/defic: consider also NIEMANN-PICK DISEASE
DUI
D013108 MeSH Browser
CUI
M0020300
CAS
Sphingomyelin cholinephosphohydrolase
Previous indexing
Phosphodiesterases (1973-1974); Sphingomyelins (1973-1974)
History note
91(75); was see under PHOSPHODIESTERASES 1975-90
Public note
91; was see under PHOSPHODIESTERASES 1975-90

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis 2
AI
antagonists & inhibitors 1
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 1
CL
classification
DF
deficiency 7
DE
drug effects
EC
economics
GE
genetics 8
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 7
PK
pharmacokinetics
PD
pharmacology 2
PH
physiology 1
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D01 Inorganic Chemicals 68
D02 Organic Chemicals 391
D03 Heterocyclic Compounds 189
D04 Polycyclic Compounds 65
D05 Macromolecular Substances 103
D06 Hormones, Hormone Substitutes, and Hormone Antagonists 43
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.277 Hydrolases 475
D08.811.277.352 Esterases 207
D08.811.277.352.640 Phosphoric Diester Hydrolases 113
D08.811.277.352.640.050 Annexin A3 1
D08.811.277.352.640.150 3',5'-Cyclic-AMP Phosphodiesterases 12
D08.811.277.352.640.155 3',5'-Cyclic-GMP Phosphodiesterases 2
D08.811.277.352.640.160 2',3'-Cyclic-Nucleotide Phosphodiesterases 3
D08.811.277.352.640.295 Glycerophosphoinositol Inositolphosphodiesterase
D08.811.277.352.640.430 Phosphodiesterase I 2
D08.811.277.352.640.700 Phospholipases 69
D08.811.277.352.640.750 Sphingomyelin Phosphodiesterase 21
D09 Carbohydrates 723
D10 Lipids 2 524
D12 Amino Acids, Peptides, and Proteins 16
D13 Nucleic Acids, Nucleotides, and Nucleosides 9
D20 Complex Mixtures 19
D23 Biological Factors 143
D25 Biomedical and Dental Materials 110
D26 Pharmaceutical Preparations 7 034
D27 Chemical Actions and Uses 374

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