Závažné vzácné onemocnění mozku postihující obv. děti a mající souvislost s virem spalniček perzistujícím v CNS. Vzniká postupně, obv. s dlouhou inkubační dobou, histologicky jsou patrné intranukleární inkluze, změny glie, perivaskulární infiltráty. Klinicky se projevuje demencí, neurologickými příznaky, cca za 1 až 3 roky dochází k úmrtí. (cit. Velký lékařský slovník online, 2014 http://lekarske.slovniky.cz)

A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)

DUI

D013344 MeSH Prohlížeč

CUI

M0020645

Předchozí užití

Cerebral Sclerosis, Diffuse (1966-1970)

Historická pozn.

71; VAN BOGAERT'S LEUKOENCEPHALITIS was see under SUBACUTE SCLEROSING PANENCEPHALITIS 1971-78; was see under CEREBRAL SCLEROSIS, DIFFUSE 1963-70

Online pozn.

use SUBACUTE SCLEROSING PANENCEPHALITIS to search VAN BOGAERT'S LEUKOENCEPHALITIS 1971-78; use CEREBRAL SCLEROSIS, DIFFUSE 1966-70

Veřejná pozn.

71; VAN BOGAERT'S LEUKOENCEPHALITIS was see under SUBACUTE SCLEROSING PANENCEPHALITIS 1971-78; was see under CEREBRAL SCLEROSIS, DIFFUSE 1963-70