A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.

DUI

D014359 MeSH Prohlížeč

CUI

M0022080

Předchozí užití

Pancreatic Juice (1972-1974); Trypsin Inhibitors (1972-1974)

Historická pozn.

91(75); was see under TRYPSIN INHIBITORS 1975-90

Veřejná pozn.

91; was see under TRYPSIN INHIBITORS 1975-90