dideoxynukleosidy [Dideoxynucleosides]

tematický
19
Termíny

2',3'-dideoxynukleosidy
dideoxyribonukleosidy

 

2',3'-Dideoxynucleosides
ddNus
Dideoxyribonucleosides

Perzistentní odkaz   https://www.medvik.cz/link/D015224
Definice

Nukleosidy, které mají z cukerné části odstraněné dvě hydroxylové skupiny. Většina těchto sloučenin má širokospektré antiretrovirové účinky, neboť působí jako antimetabolity. Tyto nukleosidy jsou v buňkách fosforylovány na 5'-trifosfátech a v této formě působí jako inhibitory reverzní transkripce u virů (ukončují elongaci řetězce DNA).

Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.

Anotace
antivirals & antimetabolites
DUI
D015224 MeSH Prohlížeč
CUI
M0023387
Předchozí užití
Deoxyribonucleosides (1971-1988)
Historická pozn.
89
Veřejná pozn.
89

1,2-dipalmitoylphosphatidyldideoxyguanosine Chemical MeSH Prohlížeč

1-(2',3'-dideoxy-3'(hydroxymethyl)erythropentofuranosyl)cytosine Chemical MeSH Prohlížeč

1-(2-fluoro-4-iodo-2,4-dideoxyxylopyranosyl)-2-nitroimidazole Chemical MeSH Prohlížeč

2',3'-deoxy-D-apio-D-furanoadenosine Chemical MeSH Prohlížeč

2',3'-didehydro-2',3'-dideoxyuridine Chemical MeSH Prohlížeč

2',3'-dideoxy-2',3'-didehydroguanine nucleoside Chemical MeSH Prohlížeč

2',3'-dideoxy-3'-O-methylthymidine Chemical MeSH Prohlížeč

2',3'-dideoxy-3'-aminoadenosine Chemical MeSH Prohlížeč

2',3'-dideoxy-3'-fluoro-2-thiothymidine Chemical MeSH Prohlížeč

2',3'-dideoxy-6-iodoguanosine Chemical MeSH Prohlížeč

2',3'-dideoxy-N(6)-cyclohexyladenosine Chemical MeSH Prohlížeč

2',3'-dideoxycarbocyclic thymidine Chemical MeSH Prohlížeč

2',3'-dideoxyformycin A Chemical MeSH Prohlížeč

2',3'-dideoxyguanosine Chemical MeSH Prohlížeč

2',3'-dideoxythymidine Chemical MeSH Prohlížeč

2',3'-dideoxyuridine Chemical MeSH Prohlížeč

2',5'-dichloro-2',5'-dideoxyuridine Chemical MeSH Prohlížeč

2'-chloro-2',3'-dideoxyuridinene Chemical MeSH Prohlížeč

2'-fluoro-2',3'-dideoxyguanosine Chemical MeSH Prohlížeč

2'-methylcarbovir Chemical MeSH Prohlížeč

2,6-diaminopurine 2',3'-didehydro-2',3'-dideoxyriboside Chemical MeSH Prohlížeč

3' (3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxyuridine Chemical MeSH Prohlížeč

3',3'-difluoro-3'-deoxythymidine Chemical MeSH Prohlížeč

3',5'-dideoxythymidine Chemical MeSH Prohlížeč

3'-(3-(2-chloroethyl)-3-nitrosourea)-3'-deoxythymidine Chemical MeSH Prohlížeč

3'-(3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxy-5-fluorouridine Chemical MeSH Prohlížeč

3'-C-methylidene-2',3'-dideoxy-5-methyluridine Chemical MeSH Prohlížeč

3'-acetamido-2',3'-dideoxythymidine Chemical MeSH Prohlížeč

3'-amino-2',3'-dideoxyuridine Chemical MeSH Prohlížeč

3'-aminothymidine Chemical MeSH Prohlížeč

3'-azido-2',3'-dideoxyguanosine Chemical MeSH Prohlížeč

3'-deoxy-2',3'-didehydro-2'fluorothymidine Chemical MeSH Prohlížeč

3'-deoxy-3'-iodothymidine Chemical MeSH Prohlížeč

3'-fluoro-2',3'-dideoxy-5-bromouridine Chemical MeSH Prohlížeč

3'-fluoro-2',3'-dideoxy-5-iodouridine Chemical MeSH Prohlížeč

3'-fluoro-2',3'-dideoxyguanosine Chemical MeSH Prohlížeč

3'-fluoro-2',3'-dideoxyuridine Chemical MeSH Prohlížeč

3'-isocyano-2',3'-dideoxyuridine Chemical MeSH Prohlížeč

3'-methylamino-2',3'-dideoxyribosylthymine Chemical MeSH Prohlížeč

3'-thio-3'-deoxythymidine Chemical MeSH Prohlížeč

3'amino-3'-deoxy-5'-glucopyranuronosylthymidine Chemical MeSH Prohlížeč

5'-amino-2',5'-dideoxyguanosine Chemical MeSH Prohlížeč

5'-amino-5'-deoxythymidine Chemical MeSH Prohlížeč

5'-deoxy-5'fluorothymidine Chemical MeSH Prohlížeč

5'-isocyano-2',5'-dideoxyuridine Chemical MeSH Prohlížeč

5'-isocyano-5'-deoxythymidine Chemical MeSH Prohlížeč

5-bromo-2',3'-dideoxyuridine Chemical MeSH Prohlížeč

5-bromo-6-methoxy-5,6-dihydro-3'-fluoro-3'-deoxythymidine Chemical MeSH Prohlížeč

5-fluoro-2',3'-dideoxy-3'-fluorouridine Chemical MeSH Prohlížeč

5-iodo-2',3'-dideoxyuridine Chemical MeSH Prohlížeč

5-iodo-6-methoxy-5,6-dihydro-3'-fluoro-3'-deoxythymidine Chemical MeSH Prohlížeč

5-o-carboranyl-2',3'-didehydro-2',3'-dideoxyuridine Chemical MeSH Prohlížeč

6-aminocarbovir Chemical MeSH Prohlížeč

6-chloro-2',3'-dideoxyguanosine Chemical MeSH Prohlížeč

6-chloro-2',3'-dideoxyinosine Chemical MeSH Prohlížeč

6-thioguanine-alpha-2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentafuranose Chemical MeSH Prohlížeč

9-(c-4,t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl)-9H-adenine Chemical MeSH Prohlížeč

N,N'-dideoxythymidine-3,4,9,10-perylene-tetracarboxylic acid diimide Chemical MeSH Prohlížeč

N-(5'-adenosyl)-N'-(5'-thymidyl)azelaamide Chemical MeSH Prohlížeč

alovudine Chemical MeSH Prohlížeč

carbocyclic 3'-oxa-2',3'-dideoxy-7-deazaguanosine Chemical MeSH Prohlížeč

carbocyclic 3'-oxa-2',3'-dideoxyguanosine Chemical MeSH Prohlížeč

carbovir Chemical MeSH Prohlížeč

carbovir-5'-O-glucuronide Chemical MeSH Prohlížeč

norabacavir Chemical MeSH Prohlížeč

norcarbovir Chemical MeSH Prohlížeč

raluridine Chemical MeSH Prohlížeč