A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

DUI

D015377 MeSH Browser

CUI

M0023687

CAS

2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))-

Previous indexing

Cyclopropanes (1983-1988); Dipeptidases/antagonists & inhibitors (1983-1988); Protease Inhibitors (1983-1988)

History note

89

Public note

89