Pentostatin [pentostatin]
topical
11
- Terms
-
2'-deoxykoformycin
deoxykoformycin
Nipent
-
2'-Deoxycoformycin
CI-825
Co-Vidarabine
Deoxycoformycin
Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
Nipent
NSC-218321
Persistent link
https://www.medvik.cz/link/D015649
Definition
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
- DUI
- D015649 MeSH Browser
- CUI
- M0023987
- CAS
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-
- Previous indexing
- Azepines (1966-1978); Coformycin/analogs & derivatives (1979-1989); Deoxyribonucleosides (1971-1978)
- History note
- 1997 (1990); for CO-VIDARABINE use PENTOSTATIN 1982-1997
- Public note
- 1997; CO-VIDARABINE (now PENTOSTATIN) was indexed under VIDARABINE/*analogs & derivatives 1976-97
Allowable subheadings
- AD
- administration & dosage 4
- AE
- adverse effects 1
- AG
- agonists
- AA
- analogs & derivatives
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology 3
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 3
- TO
- toxicity 1
- UR
- urine
...
Occurrences in Medvik records
D
Chemicals and Drugs