Oncogene Protein gp140(v-fms) [onkogenní protein gp140(v-fms)]
- Terms
-
fms Oncogene Product gp120
fms Oncogene Product gp140
fms Oncogene Protein gp120
fms Oncogene Protein gp140
gp120 v-fms
gp120(v-fms)
gp140 v-fms
gp140(v-fms)
v-fms Protein
Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).
- Annotation
- IM; coord with specific virus (IM); /drug eff /ultrastruct permitted
- DUI
- D016281 MeSH Browser
- CUI
- M0024883
- Previous indexing
- Retroviridae Proteins (1987-1989); Retroviridae Proteins, Oncogenic (1990); Oncogene Proteins, Viral (1985-1989)
- History note
- 91
- Public note
- 91
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis
- AI
- antagonists & inhibitors
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics
- PD
- pharmacology
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine