A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.

Annotation

/antag permitted but consider also ANTITOXINS

podheslo /antagonisté a inhibitory je povolené, ale zvaž také deskriptor ANTITOXINY

DUI

D016604 MeSH Browser

CUI

M0025321

CAS

Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-

Previous indexing

Aflatoxins (1966-1991)

History note

92; was AFLATOXIN B1 (NM) 1980-91

Online note

use AFLATOXIN B1 (NM) to search AFLATOXIN B1 1979-91

Public note

92; AFLATOXIN B1 was indexed under AFLATOXINS 1980-91