aflatoxin M1 [Aflatoxin M1]

tematický
4
Termíny

4-Hydroxyaflatoxin B1
Aflatoxin M
Aflatoxin M(1)
Aflatoxin M1, cis(+-)-Isomer

Perzistentní odkaz   https://www.medvik.cz/link/D016607
Definice

A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).

Anotace
/antag permitted but consider also ANTITOXINS
podheslo /antagonisté a inhibitory je povolené, ale zvaž také deskriptor ANTITOXINY
DUI
D016607 MeSH Prohlížeč
CUI
M0025324
RN
6795-23-9
CAS
Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-
Předchozí užití
Aflatoxins (1969-1991)
Historická pozn.
92; was AFLATOXIN (NM) 1980-91
Online pozn.
use AFLATOXIN M1 (NM) to search AFLATOXIN M1 1979-91
Veřejná pozn.
92; AFLATOXIN M1 was indexed under AFLATOXINS 1980-91

D Chemikálie a léčiva
D03.383.663 pyrany 43
D03.383.663.283 benzopyrany 62
D03.383.663.283.119 aflatoxiny 166
D03.383.663.283.119.075 aflatoxin B1 41
D03.383.663.283.119.100 aflatoxin M1 4
D03.633.100.150 benzopyrany 62
D03.633.100.150.119 aflatoxiny 166
D03.633.100.150.119.075 aflatoxin B1 41
D03.633.100.150.119.100 aflatoxin M1 4
D23.946.587 mykotoxiny 364
D23.946.587.142 aflatoxiny 166
D23.946.587.142.075 aflatoxin B1 41
D23.946.587.142.100 aflatoxin M1 4