A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).

Annotation

/antag permitted but consider also ANTITOXINS

podheslo /antagonisté a inhibitory je povolené, ale zvaž také deskriptor ANTITOXINY

DUI

D016607 MeSH Browser

CUI

M0025324

RN

6795-23-9

CAS

Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-

Previous indexing

Aflatoxins (1969-1991)

History note

92; was AFLATOXIN (NM) 1980-91

Online note

use AFLATOXIN M1 (NM) to search AFLATOXIN M1 1979-91

Public note

92; AFLATOXIN M1 was indexed under AFLATOXINS 1980-91