A heterogenous group of disorders characterized by alterations of mitochondrial metabolism that result in muscle and nervous system dysfunction. These are often multisystemic and vary considerably in age at onset (usually in the first or second decade of life), distribution of affected muscles, severity, and course. (From Adams et al., Principles of Neurology, 6th ed, pp984-5)

Annotation

general or unspecified; prefer specifics; coordinate with specific dysfunction if pertinent

DUI

D017237 MeSH Browser

CUI

M0026153

Previous indexing

Brain Diseases, Metabolic (1977-1992); Mitochondria, Muscle (1977-1992); Neuromuscular Diseases (1977-1992)

History note

1993

Public note

1993