Complement Factor H [komplement - faktor H]
topical
13
- Terms
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faktor H
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Factor H
Persistent link
https://www.medvik.cz/link/D017242
Definition
An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
- DUI
- D017242 MeSH Browser
- CUI
- M0026162
- CAS
- Complement factor H
- Previous indexing
- Beta Globulins (1978-1979); Complement 3b Inactivators (1980-1992); Glycoproteins (1978-1979)
- History note
- 93; was COMPLEMENT FACTOR H (NM) 1978-92
- Online note
- use COMPLEMENT FACTOR H (NM) to search COMPLEMENT FACTOR H 1978-92
- Public note
- 93; COMPLEMENT FACTOR H was indexed under COMPLEMENT 3B INACTIVATORS 1980-92 & under BETA GLOBULINS and GLYCOPROTEINS 1978-79
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 1
- AG
- agonists 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 0
- BI
- biosynthesis 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 1
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 6
- HI
- history 0
- IM
- immunology 2
- IP
- isolation & purification 1
- ME
- metabolism 2
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 2
...
Occurrences in Medvik records