Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.

Annotation

PrPC stands for PRion Protein Cellular; do not confuse with PRPSC PROTEINS which are scrapie prion proteins

DUI

D018621 MeSH Browser

CUI

M0027910

Previous indexing

Prions (1992-1994)

History note

95; SCRAPIE AMYLOID PRECURSOR PROTEIN was NM 1989-94

Online note

use PRPC PROTEINS (NM) to search SCRAPIE AMYLOID PRECURSOR PROTEIN 1989-94

Public note

95; SCRAPIE AMYLOID PRECURSOR PROTEIN was indexed under PRIONS & PROTEIN PRECURSORS 1992-94 and under VIRAL PROTEINS 1989-91