Genes, erbB-1 [geny erbB-1]
- Terms
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geny c-erbB-1
geny EGFR
geny erbB1
geny geny pro receptor epidermálního růstového faktoru
geny v-erbB
onkogeny v-erbB
protoonkogeny c-erbB-1
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c-erbB-1 Genes
c-erbB-1 Proto-Oncogenes
EGFR Genes
Epidermal Growth Factor Receptor Genes
erbB-1 Genes
Genes, EGFR
Genes, erbB1
v-erbB Genes
v-erbB Oncogenes
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
- Annotation
- spell in titles & translations as erbB-1; GENES, ERBB-2 is also available
- DUI
- D018773 MeSH Browser
- CUI
- M0028104
- Previous indexing
- Oncogenes (1986-1994); Proto-Oncogenes (1985-1994)
- History note
- 1995
- Public note
- 1995
Allowable subheadings