Antibody-Dependent Enhancement [zvýšená infektivita v přítomnosti protilátek]

topical
4
Terms

fenomén ADE
předchozími protilátkami indukované zhoršení průběhu
protilátkami zprostředkované zhoršení
protilátkami zprostředkovaný enhancement
syndrom ADE
zesílení závislé na protilátce

Persistent link   https://www.medvik.cz/link/D019067
Definition

Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.

Annotation
enhancement of viral infectivity: read MeSH definition
DUI
D019067 MeSH Browser
CUI
M0028464
History note
96
Public note
96

Allowable subheadings

DE
drug effects 1
GE
genetics
IM
immunology 2
PH
physiology
RE
radiation effects

G Phenomena and Processes
G06 Microbiological Phenomena 96
G06.920 Virus Physiological Phenomena 50
G06.920.095 Antibody-Dependent Enhancement 4
G06.920.143 Cell Transformation, Viral 60
G06.920.190 Cytopathogenic Effect, Viral 163
G06.920.225 Drug Resistance, Viral 97
G06.920.370 Hemagglutination, Viral 41
G06.920.400 Inclusion Bodies, Viral 30
G06.920.800 Viral Interference 78
G06.920.850 Viral Load 126
G06.920.863 Viral Tropism 7
G06.920.868 Virus Attachment 6
G06.920.872 Virus Inactivation 14
G06.920.875 Virus Physiological Processes obsolete
G06.920.877 Virus Integration 32
G06.920.881 Virus Internalization 26
G06.920.900 Virus Latency 25
G06.920.913 Virus Release 4
G06.920.925 Virus Replication 539
G06.920.950 Virus Uncoating 6
G12 Immune System Phenomena 249
G12.040 Antibody Affinity 39
G12.100 Antibody Specificity 605
G12.113 Antibody-Dependent Enhancement 4
G12.119 Antigen Presentation 49
G12.122 Antigen-Antibody Reactions 393
G12.125 Binding Sites, Antibody 28
G12.186 Blood Group Incompatibility 113
G12.248 CD4-CD8 Ratio 48
G12.261 Clonal Selection, Antigen-Mediated 2
G12.274 Complement Activation 96
G12.287 Cytotoxicity, Immunologic 145
G12.300 Dose-Response Relationship, Immunologic 138
G12.350 Histamine Release 69
G12.400 HIV Seronegativity 6
G12.413 Immune Evasion 28
G12.425 Immune System Processes obsolete
G12.432 Immune Reconstitution 8
G12.450 Immunity 1 625
G12.460 Immunocompetence 57
G12.470 Immunocompromised Host 239
G12.500 Immunogenetic Phenomena 15
G12.513 Immunogenicity, Vaccine 37
G12.525 Immunologic Surveillance 59
G12.535 Immunomodulation 522
G12.565 Lymphocyte Activation 468
G12.575 Lymphocyte Cooperation 8
G12.590 Immune System Exhaustion
G12.604 Neutrophil Activation 58
G12.632 Neutrophil Infiltration 8
G12.688 Phagocytosis 673
G12.800 Seroconversion 15
G12.838 Th1-Th2 Balance 18
G12.875 Transplantation Immunology 593
G12.888 Trogocytosis 1
G12.900 Tumor Escape 24

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