Thrombospondins [thrombospondiny]

topical
7
Terms

Thrombospondin

Persistent link   https://www.medvik.cz/link/D019699
Definition

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

Annotation
membrane glycoproteins; THROMBOSPONDIN 1 is also available
DUI
D019699 MeSH Browser
CUI
M0029253
Previous indexing
Glycoproteins (1981-1989); Membrane Glycoproteins (1989-1997); Platelet Membrane Glycoproteins (1992-1993)
History note
98; see THROMBOSPONDINS (NM) 1981-97
Public note
98; THROMBOSPONDIN was indexed under MEMBRANE GLYCOPROTEINS 1989-97, PLATELET MEMBRANE GLYCOPROTEINS 1992-93, & GLYCOPROTEINS 1981-89

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis 2
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 1
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 3
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D09 Carbohydrates 724
D09.400 Glycoconjugates 58
D09.400.430 Glycoproteins 638
D09.400.430.890 Membrane Glycoproteins 201
D09.400.430.890.007 AC133 Antigen 8
D09.400.430.890.014 CD47 Antigen 5
D09.400.430.890.015 CD83 Antigen
D09.400.430.890.016 Kangai-1 Protein 1
D09.400.430.890.017 Podoplanin
D09.400.430.890.018 Tetraspanin 29 9
D09.400.430.890.020 ATP-Binding Cassette Transporters 169
D09.400.430.890.034 CD58 Antigens 1
D09.400.430.890.045 Basigin 3
D09.400.430.890.050 Thy-1 Antigens 12
D09.400.430.890.114 Butyrophilins 1
D09.400.430.890.177 CD30 Ligand 2
D09.400.430.890.185 CD40 Ligand 23
D09.400.430.890.200 Cell Adhesion Molecules 309
D09.400.430.890.275 Ectodysplasins 4
D09.400.430.890.294 Endothelial Protein C Receptor 2
D09.400.430.890.312 Fas Ligand Protein 18
D09.400.430.890.331 Fertilins
D09.400.430.890.350 Fibronectins 112
D09.400.430.890.400 GAP-43 Protein 5
D09.400.430.890.448 GPI-Linked Proteins 66
D09.400.430.890.469 Hepatitis A Virus Cellular Receptor 1
D09.400.430.890.479 Hepatitis A Virus Cellular Receptor 2 7
D09.400.430.890.489 Histocompatibility Antigens Class I 109
D09.400.430.890.509 Histocompatibility Antigens Class II 65
D09.400.430.890.530 Laminin 51
D09.400.430.890.550 Lysosomal Membrane Proteins 8
D09.400.430.890.560 Mucin-1 60
D09.400.430.890.565 Mucin-3 1
D09.400.430.890.570 Myelin-Associated Glycoprotein 7
D09.400.430.890.597 OX40 Ligand 1
D09.400.430.890.611 PHEX Phosphate Regulating Neutral Endopeptidase 2
D09.400.430.890.625 Platelet Membrane Glycoproteins 33
D09.400.430.890.736 Signaling Lymphocytic Activation Molecule Family 3
D09.400.430.890.847 Syndecans 2
D09.400.430.890.895 Thrombospondins 7
D09.400.430.890.895.400 R-Spondins
D09.400.430.890.895.800 Thrombospondin 1 9
D09.400.430.890.919 Triggering Receptor Expressed on Myeloid Cells-1 4
D09.400.430.890.942 Uroplakins
D09.400.430.890.990 Variant Surface Glycoproteins, Trypanosoma 2
D09.400.430.890.993 Viral Envelope Proteins 67
D09.400.430.890.995 Zona Pellucida Glycoproteins
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 581
D12.776.395 Glycoproteins 638
D12.776.395.550 Membrane Glycoproteins 201
D12.776.395.550.007 AC133 Antigen 8
D12.776.395.550.014 CD47 Antigen 5
D12.776.395.550.015 CD83 Antigen
D12.776.395.550.016 Kangai-1 Protein 1
D12.776.395.550.017 Podoplanin
D12.776.395.550.018 Tetraspanin 29 9
D12.776.395.550.020 ATP-Binding Cassette Transporters 169
D12.776.395.550.034 CD58 Antigens 1
D12.776.395.550.045 Basigin 3
D12.776.395.550.050 Thy-1 Antigens 12
D12.776.395.550.114 Butyrophilins 1
D12.776.395.550.177 CD30 Ligand 2
D12.776.395.550.185 CD40 Ligand 23
D12.776.395.550.200 Cell Adhesion Molecules 309
D12.776.395.550.275 Ectodysplasins 4
D12.776.395.550.294 Endothelial Protein C Receptor 2
D12.776.395.550.312 Fas Ligand Protein 18
D12.776.395.550.331 Fertilins
D12.776.395.550.350 Fibronectins 112
D12.776.395.550.400 GAP-43 Protein 5
D12.776.395.550.448 GPI-Linked Proteins 66
D12.776.395.550.469 Hepatitis A Virus Cellular Receptor 1
D12.776.395.550.479 Hepatitis A Virus Cellular Receptor 2 7
D12.776.395.550.489 Histocompatibility Antigens Class I 109
D12.776.395.550.509 Histocompatibility Antigens Class II 65
D12.776.395.550.530 Laminin 51
D12.776.395.550.550 Lysosomal Membrane Proteins 8
D12.776.395.550.560 Mucin-1 60
D12.776.395.550.565 Mucin-3 1
D12.776.395.550.570 Myelin-Associated Glycoprotein 7
D12.776.395.550.597 OX40 Ligand 1
D12.776.395.550.611 PHEX Phosphate Regulating Neutral Endopeptidase 2
D12.776.395.550.625 Platelet Membrane Glycoproteins 33
D12.776.395.550.736 Signaling Lymphocytic Activation Molecule Family 3
D12.776.395.550.847 Syndecans 2
D12.776.395.550.895 Thrombospondins 7
D12.776.395.550.895.400 R-Spondins
D12.776.395.550.895.800 Thrombospondin 1 9
D12.776.395.550.919 Triggering Receptor Expressed on Myeloid Cells-1 4
D12.776.395.550.942 Uroplakins
D12.776.395.550.990 Variant Surface Glycoproteins, Trypanosoma 2
D12.776.395.550.993 Viral Envelope Proteins 67
D12.776.395.550.995 Zona Pellucida Glycoproteins
D12.776.543 Membrane Proteins 850
D12.776.543.550 Membrane Glycoproteins 201
D12.776.543.550.023 AC133 Antigen 8
D12.776.543.550.045 ADP-ribosyl Cyclase 1 44
D12.776.543.550.068 CD83 Antigen
D12.776.543.550.079 Podoplanin
D12.776.543.550.090 Tetraspanin 29 9
D12.776.543.550.147 CD47 Antigen 5
D12.776.543.550.158 CD58 Antigens 1
D12.776.543.550.170 CD27 Ligand
D12.776.543.550.182 Kangai-1 Protein 1
D12.776.543.550.187 Basigin 3
D12.776.543.550.189 Thy-1 Antigens 12
D12.776.543.550.190 Antiporters 19
D12.776.543.550.192 ATP-Binding Cassette Transporters 169
D12.776.543.550.193 B-Cell Activating Factor 37
D12.776.543.550.194 4-1BB Ligand 1
D12.776.543.550.195 Butyrophilins 1
D12.776.543.550.196 CD30 Ligand 2
D12.776.543.550.198 CD40 Ligand 23
D12.776.543.550.200 Cell Adhesion Molecules 309
D12.776.543.550.275 Ectodysplasins 4
D12.776.543.550.294 Endothelial Protein C Receptor 2
D12.776.543.550.312 Fas Ligand Protein 18
D12.776.543.550.350 Fibronectins 112
D12.776.543.550.400 GAP-43 Protein 5
D12.776.543.550.418 GPI-Linked Proteins 66
D12.776.543.550.435 Hepatitis A Virus Cellular Receptor 1
D12.776.543.550.437 Hepatitis A Virus Cellular Receptor 2 7
D12.776.543.550.439 Histocompatibility Antigens Class I 109
D12.776.543.550.440 Histocompatibility Antigens Class II 65
D12.776.543.550.450 Ion Channels 276
D12.776.543.550.500 Laminin 51
D12.776.543.550.527 Lysosomal Membrane Proteins 8
D12.776.543.550.530 Mucin-1 60
D12.776.543.550.542 Mucin-3 1
D12.776.543.550.555 Myelin-Associated Glycoprotein 7
D12.776.543.550.590 OX40 Ligand 1
D12.776.543.550.607 PHEX Phosphate Regulating Neutral Endopeptidase 2
D12.776.543.550.625 Platelet Membrane Glycoproteins 33
D12.776.543.550.712 Sarcoglycans 2
D12.776.543.550.746 Signaling Lymphocytic Activation Molecule Family 3
D12.776.543.550.779 SLC4A Proteins
D12.776.543.550.847 Syndecans 2
D12.776.543.550.895 Thrombospondins 7
D12.776.543.550.895.400 R-Spondins
D12.776.543.550.895.800 Thrombospondin 1 9
D12.776.543.550.919 Triggering Receptor Expressed on Myeloid Cells-1 4
D12.776.543.550.942 Uroplakins
D12.776.543.550.990 Variant Surface Glycoproteins, Trypanosoma 2
D12.776.543.550.993 Viral Envelope Proteins 67
D12.776.543.550.995 Zona Pellucida Glycoproteins

FIG-1 protein, C elegans Chemical MeSH Browser

GMP-33 protein, human Chemical MeSH Browser

ISM1 protein, human Chemical MeSH Browser

ISM2 protein, human Chemical MeSH Browser

R-spondin3 protein, mouse Chemical MeSH Browser

RSPO1 protein, mouse Chemical MeSH Browser

RSPO1 protein, zebrafish Chemical MeSH Browser

RSPO4 protein, mouse Chemical MeSH Browser

THSD1 protein, human Chemical MeSH Browser

THSD7A protein, human Chemical MeSH Browser

THSD7B protein, human Chemical MeSH Browser

Tmtsp protein, mouse Chemical MeSH Browser

Tsrc1 protein, mouse Chemical MeSH Browser

thrombospondin 2 Chemical MeSH Browser

thrombospondin 3 Chemical MeSH Browser

thrombospondin 4 Chemical MeSH Browser

thrombospondin type I domain containing 7A, zebrafish Chemical MeSH Browser

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