Thrombospondins [thrombospondiny]
topical
7
- Terms
-
Thrombospondin
Persistent link
https://www.medvik.cz/link/D019699
Definition
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
- Annotation
- membrane glycoproteins; THROMBOSPONDIN 1 is also available
- DUI
- D019699 MeSH Browser
- CUI
- M0029253
- Previous indexing
- Glycoproteins (1981-1989); Membrane Glycoproteins (1989-1997); Platelet Membrane Glycoproteins (1992-1993)
- History note
- 98; see THROMBOSPONDINS (NM) 1981-97
- Public note
- 98; THROMBOSPONDIN was indexed under MEMBRANE GLYCOPROTEINS 1989-97, PLATELET MEMBRANE GLYCOPROTEINS 1992-93, & GLYCOPROTEINS 1981-89
Allowable subheadings
- AD
- administration & dosage 0
- AE
- adverse effects 0
- AG
- agonists 0
- AN
- analysis 0
- AI
- antagonists & inhibitors 0
- BI
- biosynthesis 2
- BL
- blood 0
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 0
- CL
- classification 0
- DF
- deficiency 0
- DE
- drug effects 0
- EC
- economics 0
- GE
- genetics 1
- HI
- history 0
- IM
- immunology 0
- IP
- isolation & purification 0
- ME
- metabolism 3
- PK
- pharmacokinetics 0
- PD
- pharmacology 0
- PH
- physiology 0
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 0
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0
...
Occurrences in Medvik records
D
Chemicals and Drugs
D09.400.430.890.015
CD83 Antigen
D09.400.430.890.017
Podoplanin
D09.400.430.890.331
Fertilins
D09.400.430.890.469
Hepatitis A Virus Cellular Receptor 1
D09.400.430.890.895.400
R-Spondins
D09.400.430.890.942
Uroplakins
D09.400.430.890.995
Zona Pellucida Glycoproteins
D12.776.395.550.015
CD83 Antigen
D12.776.395.550.017
Podoplanin
D12.776.395.550.331
Fertilins
D12.776.395.550.469
Hepatitis A Virus Cellular Receptor 1
D12.776.395.550.895.400
R-Spondins
D12.776.395.550.942
Uroplakins
D12.776.395.550.995
Zona Pellucida Glycoproteins
D12.776.543.550.068
CD83 Antigen
D12.776.543.550.079
Podoplanin
D12.776.543.550.170
CD27 Ligand
D12.776.543.550.435
Hepatitis A Virus Cellular Receptor 1
D12.776.543.550.779
SLC4A Proteins
D12.776.543.550.895.400
R-Spondins
D12.776.543.550.942
Uroplakins
D12.776.543.550.995
Zona Pellucida Glycoproteins