Prolinem řízená serin/threoninová proteinkináza, která zprostředkovává přenos signálu z buněčného povrchu do jádra. Aktivace tohoto enzymu fosforylací vede k jeho translokaci do jádra, kde působí na specifické transkripční faktory. K izoformám patří p40 MAPK a p41 MAPK.

A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.

Anotace

Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases

DUI

D019950 MeSH Prohlížeč

CUI

M0029623

Předchozí užití

Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1997); Protein Kinases (1992); Protein-Serine-Threonine Kinases (1993-1995); Protein-Tyrosine Kinase (1992-1997)

Historická pozn.

2005(1992)

Veřejná pozn.

2000; see P42 MAP KINASE 2000-2004, see P42(MAPK) KINASE 1998-1999; P42(MAPK) KINASE was indexed under CALMODULIN-DEPENDENT PROTEIN KINASES 1994-1997, PROTEIN-TYROSINE KINASE 1992-1997, PROTEIN-SERINE-THREONINE KINASES 1993-1995 & PROTEIN KINASES 1992; ERK2 BRAIN KINASE PK40 was indexed under PROTEIN-SERINE-THREONINE KINASES 1995-1999; ERK2 was indexed under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1998-1999, CALMODULIN-DEPENDENT KINASES 1994-1997, PROTEIN-SERINE-THREONINE KINASES 1992-1993 & PROTEIN KINASES 1992; ERK2 MBP-KINASE was indexed under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1998-1999 & CALMODULIN-DEPENDENT KINASES 1994-1997