Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- acetylcholinesterasa krev MeSH
- bránice účinky léků enzymologie MeSH
- časové faktory MeSH
- chování zvířat účinky léků MeSH
- játra účinky léků enzymologie MeSH
- krysa rodu Rattus MeSH
- LD50 MeSH
- mozek účinky léků enzymologie MeSH
- organothiofosforové sloučeniny toxicita MeSH
- potkani Wistar MeSH
- tkáňová distribuce účinky léků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- organothiofosforové sloučeniny MeSH
- S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate MeSH Prohlížeč
The toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agents--Russian VX (RVX;N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD(50) dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only by 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 35% and 15% at 30 min. While AChE and BChE activities were reduced only about 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potently inhibits ChE outside the central nervous system.
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Adv Clin Chem. 2004;38:151-216 PubMed
Neurotoxicol Teratol. 1994 Mar-Apr;16(2):145-8 PubMed
J Appl Toxicol. 2007 Sep-Oct;27(5):458-63 PubMed
Heart Lung. 1994 Nov-Dec;23(6):466-72 PubMed
J Appl Toxicol. 2007 Sep-Oct;27(5):482-90 PubMed
Neurotox Res. 2004;6(7-8):565-70 PubMed
Biochem Pharmacol. 1961 Jul;7:88-95 PubMed
J Intensive Care Med. 2004 Jan-Feb;19(1):22-37 PubMed
Toxicology. 2008 Feb 3;244(1):35-41 PubMed
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1991;34(1):5-77 PubMed
Drug Chem Toxicol. 2009;32(1):1-8 PubMed
Chem Biol Interact. 2007 Jan 5;165(1):14-21 PubMed
J Toxicol Clin Toxicol. 2002;40(6):803-16 PubMed
J Appl Toxicol. 1998 Sep-Oct;18(5):337-47 PubMed
Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):389-94 PubMed
Neurotox Res. 2006 Jun;9(4):291-6 PubMed
Br J Ind Med. 1992 Sep;49(9):648-53 PubMed
Drug Chem Toxicol. 2007;30(1):31-40 PubMed
QJM. 2006 Aug;99(8):513-22 PubMed
Int J Toxicol. 2006 Sep-Oct;25(5):397-401 PubMed
Sensors (Basel). 2008 Sep 01;8(9):5229-5237 PubMed
