Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Acetylcholinesterase blood MeSH
- Diaphragm drug effects enzymology MeSH
- Time Factors MeSH
- Behavior, Animal drug effects MeSH
- Liver drug effects enzymology MeSH
- Rats MeSH
- Lethal Dose 50 MeSH
- Brain drug effects enzymology MeSH
- Organothiophosphorus Compounds toxicity MeSH
- Rats, Wistar MeSH
- Tissue Distribution drug effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Organothiophosphorus Compounds MeSH
- S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate MeSH Browser
The toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agents--Russian VX (RVX;N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD(50) dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only by 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 35% and 15% at 30 min. While AChE and BChE activities were reduced only about 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potently inhibits ChE outside the central nervous system.
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