Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
17364862
DOI
10.1080/01480540601017637
PII: 769425028
Knihovny.cz E-zdroje
- MeSH
- chemické bojové látky chemie toxicita MeSH
- cholinesterasové inhibitory chemie toxicita MeSH
- dursban chemie toxicita MeSH
- krysa rodu Rattus MeSH
- mozek enzymologie MeSH
- obidoxim chlorid chemie farmakologie MeSH
- organofosfáty chemie toxicita MeSH
- organofosforové sloučeniny chemie toxicita MeSH
- organothiofosforové sloučeniny chemie toxicita MeSH
- oximy chemie farmakologie MeSH
- potkani Wistar MeSH
- pralidoximové sloučeniny chemie farmakologie MeSH
- pyridinové sloučeniny chemie farmakologie MeSH
- reaktivátory cholinesterázy chemie farmakologie MeSH
- sarin chemie toxicita MeSH
- soman chemie toxicita MeSH
- tkáňové extrakty MeSH
- trimedoxim chemie farmakologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- asoxime chloride MeSH Prohlížeč
- chemické bojové látky MeSH
- cholinesterasové inhibitory MeSH
- cyclohexyl methylphosphonofluoridate MeSH Prohlížeč
- dursban MeSH
- N,N'-monomethylenebis(pyridiniumaldoxime) MeSH Prohlížeč
- obidoxim chlorid MeSH
- organofosfáty MeSH
- organofosforové sloučeniny MeSH
- organothiofosforové sloučeniny MeSH
- oximy MeSH
- pralidoxime MeSH Prohlížeč
- pralidoximové sloučeniny MeSH
- pyridinové sloučeniny MeSH
- reaktivátory cholinesterázy MeSH
- sarin MeSH
- soman MeSH
- tabun MeSH Prohlížeč
- tkáňové extrakty MeSH
- trimedoxim MeSH
- VX MeSH Prohlížeč
In vitro comparison of reactivation efficacy of five currently used oximes - pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6 (at two concentrations: 10-5 and 10-3 M) - against acetylcholinesterase (AChE; E.C. 3.1.1.7) inhibited by six different nerve agents (VX, Russian VX, sarin, cyclosarin, tabun, soman) and organophosphorus insecticide chlorpyrifos was the aim of this study. As a source of AChE in the experiments, rat brain homogenate was used. According to the results obtained, no AChE reactivator was able to reach sufficient potency for AChE inhibited by all nerve agents used. Moreover, oxime HI-6 (the most effective one) was not able to reactivate tabun- and soman-inhibited AChE. Due to this fact, it could be designated as a partially broad-spectrum reactivator.
Citace poskytuje Crossref.org
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