Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
17364862
DOI
10.1080/01480540601017637
PII: 769425028
Knihovny.cz E-resources
- MeSH
- Chemical Warfare Agents chemistry toxicity MeSH
- Cholinesterase Inhibitors chemistry toxicity MeSH
- Chlorpyrifos chemistry toxicity MeSH
- Rats MeSH
- Brain enzymology MeSH
- Obidoxime Chloride chemistry pharmacology MeSH
- Organophosphates chemistry toxicity MeSH
- Organophosphorus Compounds chemistry toxicity MeSH
- Organothiophosphorus Compounds chemistry toxicity MeSH
- Oximes chemistry pharmacology MeSH
- Rats, Wistar MeSH
- Pralidoxime Compounds chemistry pharmacology MeSH
- Pyridinium Compounds chemistry pharmacology MeSH
- Cholinesterase Reactivators chemistry pharmacology MeSH
- Sarin chemistry toxicity MeSH
- Soman chemistry toxicity MeSH
- Tissue Extracts MeSH
- Trimedoxime chemistry pharmacology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- asoxime chloride MeSH Browser
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- cyclohexyl methylphosphonofluoridate MeSH Browser
- Chlorpyrifos MeSH
- N,N'-monomethylenebis(pyridiniumaldoxime) MeSH Browser
- Obidoxime Chloride MeSH
- Organophosphates MeSH
- Organophosphorus Compounds MeSH
- Organothiophosphorus Compounds MeSH
- Oximes MeSH
- pralidoxime MeSH Browser
- Pralidoxime Compounds MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
- Sarin MeSH
- Soman MeSH
- tabun MeSH Browser
- Tissue Extracts MeSH
- Trimedoxime MeSH
- VX MeSH Browser
In vitro comparison of reactivation efficacy of five currently used oximes - pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6 (at two concentrations: 10-5 and 10-3 M) - against acetylcholinesterase (AChE; E.C. 3.1.1.7) inhibited by six different nerve agents (VX, Russian VX, sarin, cyclosarin, tabun, soman) and organophosphorus insecticide chlorpyrifos was the aim of this study. As a source of AChE in the experiments, rat brain homogenate was used. According to the results obtained, no AChE reactivator was able to reach sufficient potency for AChE inhibited by all nerve agents used. Moreover, oxime HI-6 (the most effective one) was not able to reactivate tabun- and soman-inhibited AChE. Due to this fact, it could be designated as a partially broad-spectrum reactivator.
References provided by Crossref.org
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents
Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
Amperometric Biosensors for Real Time Assays of Organophosphates
