Role of mtDNA disturbances in the pathogenesis of Alzheimer's and Parkinson's disease
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
32502755
DOI
10.1016/j.dnarep.2020.102871
PII: S1568-7864(20)30119-1
Knihovny.cz E-zdroje
- Klíčová slova
- Alzheimer’s disease, Mitochondrial DNA disturbances, Neuroinflammation, Oxidative stress, Parkinson’s disease, Peptide and protein aggregation,
- MeSH
- alfa-synuklein metabolismus MeSH
- Alzheimerova nemoc etiologie genetika MeSH
- amyloidní beta-protein metabolismus MeSH
- lidé MeSH
- mitochondriální DNA * MeSH
- mutace * MeSH
- Parkinsonova nemoc etiologie genetika MeSH
- patologická konformace proteinů MeSH
- poškození DNA * MeSH
- proteiny tau metabolismus MeSH
- zánět MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- alfa-synuklein MeSH
- amyloidní beta-protein MeSH
- mitochondriální DNA * MeSH
- proteiny tau MeSH
Neurodegenerative diseases (e.g. Alzheimer's and Parkinson's disease) are becoming increasingly problematic to healthcare systems. Therefore, their underlying mechanisms are trending topics of study in medicinal research. Numerous studies have evidenced a strong association between mitochondrial DNA disturbances (e.g. oxidative damage, mutations, and methylation shifts) and the initiation and progression of neurodegenerative diseases. Therefore, this review discusses the risk and development of neurodegenerative diseases in terms of disturbances in mitochondrial DNA and as a part of a complex ecosystem that includes other important mechanisms (e.g. neuroinflammation and the misfolding and aggregation of amyloid-β peptides, α-synuclein, and tau proteins). In addition, the influence of individual mitochondrial DNA haplogroups on the risk and development of neurodegenerative diseases is also described and discussed.
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