Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
Language English Country Great Britain, England Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30728420
PubMed Central
PMC6365527
DOI
10.1038/s41598-018-37837-4
PII: 10.1038/s41598-018-37837-4
Knihovny.cz E-resources
- MeSH
- Diaphragm drug effects injuries MeSH
- Muscle, Skeletal drug effects injuries MeSH
- Rats MeSH
- Myositis chemically induced MeSH
- Necrosis MeSH
- Oximes toxicity MeSH
- Rats, Wistar MeSH
- Pyridinium Compounds toxicity MeSH
- Heart drug effects MeSH
- Muscles drug effects pathology MeSH
- Toxicity Tests, Acute MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide MeSH Browser
- 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane MeSH Browser
- K075 compound MeSH Browser
- Oximes MeSH
- Pyridinium Compounds MeSH
Therapeutic application of newly developed oximes is limited due to their adverse effects on different tissues. Within this article, it has been investigated which morphological changes could be observed in Wistar rats after the treatment with increasing doses of selected acetyl cholinesterase reactivators - asoxime, obidoxime, K027, K048, and K075. Subsequently, heart, diaphragm and musculus popliteus were obtained for pathohistological and semiquantitative analysis 24 hrs and 7 days after im administration of a single dose of 0.1 LD50, 0.5 LD50, and 1.0 LD50 of each oxime. Different muscle damage score was based on an estimation scale from 0 (no damage) to 5 (strong damage). In rats treated with 0.1 LD50 of each oxime, muscle fibres did not show any change. The intensive degeneration was found in all muscles after treatment with 0.5 LD50 of asoxime and obidoxime, respectively. Acute toxic muscle injury was developed within 7 days following treatment with 0.5 LD50 and 1.0 LD50 of each oxime, with the highest values in K048 and K075 group (P < 0.001 vs. control and asoxime), respectively. The early muscle alterations observed in our study seem to contribute to the pathogenesis of the oxime-induced toxic muscle injury, which probably manifests as necrosis and/or inflammation.
Faculty of Medicine of the Military Medical Academy University of Defence Belgrade Serbia
National Poison Control Centre Military Medical Academy Belgrade Serbia
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