TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- chromatografie na tenké vrstvě metody MeSH
- methansulfonáty izolace a purifikace MeSH
- oximy izolace a purifikace MeSH
- pyridinové sloučeniny chemická syntéza izolace a purifikace MeSH
- reaktivátory cholinesterázy chemická syntéza izolace a purifikace MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- asoxime chloride MeSH Prohlížeč
- methansulfonáty MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- reaktivátory cholinesterázy MeSH
In this study, several thin-layer chromatography (TLC) methods are described for the identification of quaternary and non-quaternary compounds (parent compounds, intermediates, by-products, and products) arisen within the synthesis of the acetylcholinesterase reactivator HI-6, at present the most promising antidote in the case of nerve agent poisonings. Using the TLC technique, particular E and Z isomers of this compound on the oxime group are separated. These TLC methods could be of high interest as quick purity control for those who are interested in development of new acetylcholinesterase reactivators and the synthesis of HI-6 in laboratories or in large-scale production.
Citace poskytuje Crossref.org
Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl
Combined Pre- and Posttreatment of Paraoxon Exposure
Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes
Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
