TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Chromatography, Thin Layer methods MeSH
- Mesylates isolation & purification MeSH
- Oximes isolation & purification MeSH
- Pyridinium Compounds chemical synthesis isolation & purification MeSH
- Cholinesterase Reactivators chemical synthesis isolation & purification MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- asoxime chloride MeSH Browser
- Mesylates MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
In this study, several thin-layer chromatography (TLC) methods are described for the identification of quaternary and non-quaternary compounds (parent compounds, intermediates, by-products, and products) arisen within the synthesis of the acetylcholinesterase reactivator HI-6, at present the most promising antidote in the case of nerve agent poisonings. Using the TLC technique, particular E and Z isomers of this compound on the oxime group are separated. These TLC methods could be of high interest as quick purity control for those who are interested in development of new acetylcholinesterase reactivators and the synthesis of HI-6 in laboratories or in large-scale production.
References provided by Crossref.org
Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl
Combined Pre- and Posttreatment of Paraoxon Exposure
Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes
Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
