Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
14505667
DOI
10.1016/s0960-894x(03)00751-0
PII: S0960894X03007510
Knihovny.cz E-resources
- MeSH
- Cholinesterase Inhibitors pharmacology MeSH
- Enzyme Reactivators chemical synthesis MeSH
- Kinetics MeSH
- Organophosphates pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cholinesterase Inhibitors MeSH
- Enzyme Reactivators MeSH
- Organophosphates MeSH
- tabun MeSH Browser
Synthesis of a new asymmetric bisquaternary reactivator of tabun-inhibited acetylcholinesterase-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide is described. Reactivation potency of this oxime is compared to the currently used reactivators-pralidoxime, obidoxime and H-oxime HI-6.
References provided by Crossref.org
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents
Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes
Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system
The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure
Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes
